Overclocking results will definitely be worse with 4 slots populated on a dual-channel platform. If you are lucky you could get slightly better results due to rank interleaving, but more likely overall performance will be worse because the motherboard applies slower secondary and tertiary timings to keep the high frequency stable with many ranks. If you can push the memory speed to the same frequency with all slots populated, you end up with about the same performance. The more Slots are populated (and the more ranks the memory modules have) the lower the maximum supported memory frequency. You can see this in effect with the memory speeds that are officially supported by AMD Ryzen CPUs: Full Population of ram memory slots vs half population, dual channel - CFD Online Discussion Forums
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